Pharm FLASH CARD : Cardiovascular VOCA 2(29P)

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Voice Serena

Created 4/28/2026 6:26 PM

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1. PHARM CARDIOVASCULAR TISSUE PLASMINOGEN ACTIVATORS (tPA)

Class thrombolytics fibrinolytics

Suffix ASE

alteplase Activase

reteplase Retavase

tenecteplase TNKase

streptokinase

Mechanism of Action

tPA binds to the fibrin of an existing clot, and actively busts it apart or dissolves it.

Commonly called clot busters!

Therapeutic Uses

Ischemic stroke

MI Myocardial Infarction

Pulmonary embolism

Contraindications

Active bleeding

Recent head trauma

Aneurysms or AV malformation

History of hemorrhagic stroke

Uncontrolled HTN

An risk of bleeding is SERIOUS in these patients. do not give